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A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting.

Genes, brain, and behavior - 1 Apr 2022

Sanchez-Roige Sandra, Barnes Samuel A, Mallari Jazlene, Wood Rebecca, Polesskaya Oksana, Palmer Abraham A

Abstract excerpt

The neuronal membrane glycoprotein M6B (Gpm6b) gene encodes a membrane glycoprotein that belongs to the proteolipid protein family, and is enriched in neurons, oligodendrocytes, and subset of astrocytes in the central nervous system. GPM6B is thought to play a role in neuronal differentiation, myelination, and inactivation of the serotonin transporter via internalization. Recent human genome-wide association...

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PMID: 35243767
DOI: 10.1111/gbb.12800
PMCID: PMC9211103

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