Mechanism of antigen-driven selection in germinal centres.

doi:10.1038/342929a0

Back to search

Article

Mechanism of antigen-driven selection in germinal centres.

Nature - 1 Jan 2000

Liu Y J, Joshua D E, Williams G T, Smith C A, Gordon J, MacLennan I C

Abstract excerpt

The high affinity of antibodies produced during responses to T-cell-dependent antigens is associated with somatic mutation in the variable region of the immunoglobulin. Indirect evidence indicates that: (1) this arises by a process of hypermutation, acting selectively on rearranged immunoglobulin...

Topics

Antibodies
Antigens, CD
Antigens, Surface
B-Lymphocytes
Cell Survival
Cells, Cultured
Culture Techniques
Cytotoxicity, Immunologic
Humans
Palatine Tonsil
Phenotype

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.