Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of antigen-driven selection in germinal centres.

Nature - 1 Jan 2000

Liu Y J, Joshua D E, Williams G T, Smith C A, Gordon J, MacLennan I C

Abstract excerpt

The high affinity of antibodies produced during responses to T-cell-dependent antigens is associated with somatic mutation in the variable region of the immunoglobulin. Indirect evidence indicates that: (1) this arises by a process of hypermutation, acting selectively on rearranged immunoglobulin variable-region genes, which is activated in centroblasts within germinal centres; and (2) centrocytes, the progeny of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Antigens, CD
Share to Antigens, Surface

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to B-Lymphocytes

Share to Cell Survival

Share to Cells, Cultured

Share to Cytotoxicity, Immunologic

Share to Phenotype

Source

Identifiers

PMID: 2594086
DOI: 10.1038/342929a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of antigen-driven selection in germinal centres.PMID 2594086Read ↗

An analysis of B cell selection mechanisms in germinal centersSemantic proximity Read ↗

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblasts.Semantic proximity Read ↗

Somatic mutation leads to efficient affinity maturation when centrocytes recycle back to centroblastsSemantic proximity Read ↗

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.Semantic proximity Read ↗

Suppressive might of a few: T follicular regulatory cells impede auto-reactivity despite being outnumbered in the germinal centresSemantic proximity Read ↗

Accumulation of somatic hypermutation and antigen-driven selection in rapidly cycling surface Ig+ germinal center (GC) B cells which occupy GC at a high frequency during the primary anti-hapten response in mice.Semantic proximity Read ↗

Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees.Semantic proximity Read ↗

The human CD77- B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision.Semantic proximity Read ↗

Mechanisms of selection and differentiation in germinal centers.Semantic proximity Read ↗

Maturation and Dispersal of B‐Cell Clones during T Cell‐Dependent Antibody ResponsesSemantic proximity Read ↗

Follicular Lymphoma Cell Lines, an <i>In Vitro</i> Model for Antigenic Selection and Cytokine‐Mediated Growth Regulation of Germinal Centre B CellsSemantic proximity Read ↗

Quantitative analysis of molecules which distinguish functional compartments within germinal centers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.