Article
Association of Janus kinase 2 (JAK2) polymorphisms with acute leukemia susceptibility.
International journal of laboratory hematology - 1 Jun 2012
Zhong Y, Wu J, Ma R, Cao H, Wang Z, Ding J, Cheng L, Feng J, Chen B
Abstract excerpt
INTRODUCTION: Aberrant activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway leads to deregulated proliferation, differentiation, or apoptosis of normal cells. One of the members of this family, JAK2, plays a very important role in metabolizing carcinogens and medications. This study aimed to detect whether any association exists between genetic polymorphisms in JAK2...
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