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Article

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

The Journal of cell biology - 11 May 2015

O'Regan Laura, Sampson Josephina, Richards Mark W, Knebel Axel, Roth Daniel, Hood Fiona E, Straube Anne, Royle Stephen J, Bayliss Richard, Fry Andrew M

Abstract excerpt

Hsp70 proteins represent a family of chaperones that regulate cellular homeostasis and are required for cancer cell survival. However, their function and regulation in mitosis remain unknown. In this paper, we show that the major inducible cytoplasmic Hsp70 isoform, Hsp72, is required for assembl...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25940345
DOI: 10.1083/jcb.201409151
PMCID: PMC4427782

Genes

TACC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25940345-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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