Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.

doi:10.1073/pnas.1715874115

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Article

Resource limitation prevents the emergence of drug resistance by intensifying within-host competition.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2017

Wale Nina, Sim Derek G, Jones Matthew J, Salathe Rahel, Day Troy, Read Andrew F

Abstract excerpt

Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully treat infectious diseases. Whether a drug-resistant mutant grows to high densities, and so sickens the patient and spreads to new hosts, is determined by the competitive interactions it has with drug-susceptible pathogens within the host. Competitive interactions thus represent a good target for resistance...

Topics

Drug Resistance
Host-Parasite Interactions
Malaria
Models, Biological
Mutation
Plasmodium chabaudi

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Identifiers

PMID: 29233945
DOI: 10.1073/pnas.1715874115
PMCID: PMC5748215

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