Article
Competitive release of drug resistance following drug treatment of mixed Plasmodium chabaudi infections.
Malaria journal - 14 Sept 2004
de Roode Jacobus C, Culleton Richard, Bell Andrew S, Read Andrew F
Abstract excerpt
BACKGROUND: Malaria infections are often genetically diverse, potentially leading to competition between co-infecting strains. Such competition is of key importance in the spread of drug resistance. METHODS: The effects of drug treatment on within-host competition were studied using the rodent malaria Plasmodium chabaudi. Mice were infected simultaneously with a drug-resistant and a drug-sensitive clone and were...
Topics
- Animals
- Anopheles
- Antimalarials
- Drug Resistance
- Female
- Genotype
- Insect Vectors
- Malaria
- Mice
- Mice, Inbred CBA
- Plasmodium chabaudi
- Pyrimethamine