Article
Equivalence of kernel machine regression and kernel distance covariance for multidimensional phenotype association studies.
Biometrics - 1 Sept 2015
Hua Wen-Yu, Ghosh Debashis
Abstract excerpt
Associating genetic markers with a multidimensional phenotype is an important yet challenging problem. In this work, we establish the equivalence between two popular methods: kernel-machine regression (KMR), and kernel distance covariance (KDC). KMR is a semiparametric regression framework that models covariate effects parametrically and genetic markers non-parametrically, while KDC represents a class of methods...
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