Elevated Lipoprotein(a) Does Not Cause Low-Grade Inflammation Despite Causal Association With Aortic Valve Stenosis and Myocardial Infarction: A Study of 100,578 Individuals from the General Population.

Abstract excerpt

CONTEXT: It is unknown whether elevated lipoprotein(a) is causally associated with low-grade inflammation. OBJECTIVE: We tested the hypothesis that elevated lipoprotein(a) is observationally and causally associated with low-grade inflammation together with aortic valve stenosis and myocardial infarction. DESIGN AND SETTING: Using a multidirectional Mendelian randomization approach, we studied 100,578 individuals...

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