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Article

A thorough assessment of benign genetic variability in GRN and MAPT.

Human mutation - 1 Feb 2010

Guerreiro Rita J, Washecka Nicole, Hardy John, Singleton Andrew

Abstract excerpt

Mutations in APP, PSEN1, MAPTand GRNare the most common genetic causes of dementia. The previous miss-assignment of pathogenicity to benign variants in these genes stresses the importance of discerning between disease causing mutations and benign variants with no pathogenic effect on the function of the respective protein. In this study we sequenced GRNand MAPTin 282 samples from the Centre d'Etude du...

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Source

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Identifiers

PMID: 20020531
DOI: 10.1002/humu.21152
PMCID: PMC2815037

Genes

APP
GRN
MAPT
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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