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Article

A thorough assessment of benign genetic variability in GRN and MAPT.

Human mutation - 1 Feb 2010

Guerreiro Rita J, Washecka Nicole, Hardy John, Singleton Andrew

Abstract excerpt

Mutations in APP, PSEN1, MAPTand GRNare the most common genetic causes of dementia. The previous miss-assignment of pathogenicity to benign variants in these genes stresses the importance of discerning between disease causing mutations and benign variants with no pathogenic effect on the function...

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Source

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Identifiers

PMID: 20020531
DOI: 10.1002/humu.21152
PMCID: PMC2815037

Genes

APP
GRN
MAPT
PSEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-20020531-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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