Article
Epigenetic regulation of differential HLA-A allelic expression levels.
Human molecular genetics - 1 Aug 2015
Ramsuran Veron, Kulkarni Smita, O'huigin Colm, Yuki Yuko, Augusto Danillo G, Gao Xiaojiang, Carrington Mary
Abstract excerpt
MHC class I expression levels influence the strength of immune responses and represent another variable in determining outcome to disease beyond peptide binding alone. Identification of the HLA loci that vary in allelic expression levels and delineating the mechanism responsible for expression variation may provide the opportunity to modify their expression therapeutically. We have examined the expression levels...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.