Article
A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Nicholas Ben, Staples Karl J, Moese Stefan, Meldrum Eric, Ward Jon, Dennison Patrick, Havelock Tom, Hinks Timothy S C, Amer Khalid, Woo Edwin, Chamberlain Martin, Singh Neeta, North Malcolm, Pink Sandy, Wilkinson Tom M A, Djukanović Ratko
Abstract excerpt
Influenza A virus causes considerable morbidity and mortality largely because of a lack of effective antiviral drugs. Viral neuraminidase inhibitors, which inhibit viral release from the infected cell, are currently the only approved drugs for influenza, but have recently been shown to be less effective than previously thought. Growing resistance to therapies that target viral proteins has led to increased...
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