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Article

Imputation-based population genetics analysis of Plasmodium falciparum malaria parasites.

PLoS genetics - 1 Apr 2015

Samad Hanif, Coll Francesc, Preston Mark D, Ocholla Harold, Fairhurst Rick M, Clark Taane G

Abstract excerpt

Whole-genome sequencing technologies are being increasingly applied to Plasmodium falciparum clinical isolates to identify genetic determinants of malaria pathogenesis. However, genome-wide discovery methods, such as haplotype scans for signatures of natural selection, are hindered by missing genotypes in sequence data. Poor correlation between single nucleotide polymorphisms (SNPs) in the P. falciparum genome...

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Identifiers

PMID: 25928499
DOI: 10.1371/journal.pgen.1005131
PMCID: PMC4415759

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