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Article

Imputation without doing imputation: a new method for the detection of non-genotyped causal variants.

Genetic epidemiology - 1 Apr 2014

Howey Richard, Cordell Heather J

Abstract excerpt

Genome-wide association studies allow detection of non-genotyped disease-causing variants through testing of nearby genotyped SNPs. This approach may fail when there are no genotyped SNPs in strong LD with the causal variant. Several genotyped SNPs in weak LD with the causal variant may, however, considered together, provide equivalent information. This observation motivates popular but computationally intensive...

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PMID: 24535679
DOI: 10.1002/gepi.21792
PMCID: PMC4150535

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