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The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

30 Apr 2015

Abstract excerpt

The development of molecularly targeted anticancer agents relies on large panels of tumour-specific preclinical models closely recapitulating the molecular heterogeneity observed in patients. Here we describe the mutational and gene expression analyses of 151 colorectal cancer (CRC) cell lines. We find that the whole spectrum of CRC molecular and transcriptional subtypes, previously defined in patients, is...

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PMID: 25926053
DOI: 10.1038/ncomms8002

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