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Mechanisms of resistance to EGFR-targeted therapies in colorectal cancer: more than just genetics

15 Sept 2023

Abstract excerpt

The development of acquired resistance to anti-EGFR therapies remains poorly understood, with most research to date exploring, and trying to overcome, various genomic mechanisms of resistance. However, recent work supports a model of resistance whereby transcriptomic mechanisms of resistance predominate in the presence of active cytotoxic chemotherapy combined with anti-EGFR therapy in the first-line setting,...

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Cancer Genomics and Diagnostics
Colorectal Cancer Treatments and Studies
Lung Cancer Treatments and Mutations

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37791069
DOI: 10.3389/fcell.2023.1176657

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