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Article

Association of IL-12, IL-18 variants and serum IL-18 with bladder cancer susceptibility in North Indian population.

Gene - 25 Apr 2013

Jaiswal Praveen Kumar, Singh Vibha, Srivastava Priyanka, Mittal Rama Devi

Abstract excerpt

IL-12 and IL-18 are immunomodulatory cytokines that play important roles in host immune response against cancers. Variation in DNA sequence in gene promoter may lead to altered IL-18 production and/or activity, and hence can modulate an individual's susceptibility to BC. To test this hypothesis, we investigated the relationship of IL-18 gene promoter -137 G/C and -607C/A polymorphisms and IL12 (-16974) A/C with...

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PMID: 23403235
DOI: 10.1016/j.gene.2013.01.025

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