Article
Interleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate cancer risk.
Molecular biology reports - 1 Jan 2013
Magalhães J F, Cortinhas A J, Albuquerque C M, Baptista C S, Ribeiro R, Viegas Carlos, Matos Augusto, Machado João, Pires Maria A, Guedes-Pinto Henrique, Martins-Bessa A, Leitão J C, Bastos E
Abstract excerpt
Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes, IL-6 polymorphisms may modulate PCa risk. IL-6 -174 G>C (rs 1800795, also designated -236 G>C) and -636 G>C (rs 1800796, also designated -572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit...
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