Article
Mutations in FL5.12 cells conferring resistance to apoptosis induced by interleukin-3 deprivation.
International journal of oncology - 1 Jan 1999
Zhang H, Brandt R, Heim J, Meyhack B
Abstract excerpt
In an attempt to dissect the signal pathway in which Bax increases cellular responses to apoptotic stimuli and leads to the activation of the caspase cascade, we mutated FL5.12 Bax CL16 cells with a chemical mutagen. In this report we characterize two mutant clones, FL5.12 ms1 and m3. Both clones...
Topics
- Animals
- Apoptosis
- B-Lymphocytes
- Caspase 3
- Caspases
- Cell Line
- Hematopoietic Stem Cells
- Interleukin-3
- Mice
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- bcl-2-Associated X Protein