Article
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one - 1 Jan 2012
Pelosi Elvira, Castelli Germana, Martin-Padura Ines, Bordoni Veronica, Santoro Simona, Conigliaro Alice, Cerio Anna Maria, De Santis Puzzonia Marco, Marighetti Paola, Biffoni Mauro, Alonzi Tonino, Amicone Laura, Alcalay Myriam, Bertolini Francesco, Testa Ugo, Tripodi Marco
Abstract excerpt
Embryologic and genetic evidence suggest a common origin of haematopoietic and endothelial lineages. In the murine embryo, recent studies indicate the presence of haemogenic endothelium and of a common haemato-endothelial precursor, the haemangioblast. Conversely, so far, little evidence supports the presence of haemogenic endothelium and haemangioblasts in later stages of development. Our studies indicate that...
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