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Article

Intestinal genetic inactivation of caspase-8 diminishes migration of enterocytes.

World journal of gastroenterology - 21 Apr 2015

Kaemmerer Elke, Kuhn Paula, Schneider Ursula, Jeon Min Kyung, Klaus Christina, Schiffer Miriam, Weisner Danika, Liedtke Christian, Jäkel Jörg, Kennes Lieven Nils, Hilgers Ralf-Dieter, Wagner Norbert, Gassler Nikolaus

Abstract excerpt

AIM: To verify the hypothesis that caspase-8 (Casp8), which regulates cellular apoptosis and necroptosis, is critically involved in enterocyte migration. METHODS: Casp8-silenced Caco2 cells were used in migration assays. In addition, enterocyte-specific Casp8 heterozygous (Casp8(+/∆int)) or homozygous knockout mice (Casp8(∆int)) were generated by crossing genetically modified mice carrying loxP recombination...

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Identifiers

PMID: 25914458
DOI: 10.3748/wjg.v21.i15.4499
PMCID: PMC4402296

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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