Article
Phosphorylation of Smad2/3 at specific linker threonine indicates slow-cycling intestinal stem-like cells before reentry to cell cycle.
Digestive diseases and sciences - 1 Feb 2015
Kishimoto Masanobu, Fukui Toshiro, Suzuki Ryo, Takahashi Yu, Sumimoto Kimi, Okazaki Takashi, Sakao Masayuki, Sakaguchi Yutaku, Yoshida Katsunori, Uchida Kazushige, Nishio Akiyoshi, Matsuzaki Koichi, Okazaki Kazuichi
Abstract excerpt
BACKGROUND: Quiescent (slow-cycling) and active (rapid-cycling) stem cells are demonstrated in small intestines. We have identified significant expression of Smad2/3, phosphorylated at specific linker threonine residues (pSmad2/3L-Thr), in murine stomach, and suggested these cells are epithelial stem cells. AIM: Here, we explore whether pSmad2/3L-Thr could serve as a biomarker for small intestine and colon stem...
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