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Article

Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2014

Luo Susan Y, Sit Ko-Yung, Sihoe Alan D L, Suen Wai-Sing, Au Wing-Kuk, Tang Ximing, Ma Edmond S K, Chan Wai-Kong, Wistuba Ignacio I, Minna John D, Tsao George S W, Lam David C L

Abstract excerpt

BACKGROUND: Large tumor suppressor 2 (LATS2) gene is a putative tumor suppressor gene with potential roles in regulation of cell proliferation and apoptosis in lung cancer. The aim of this study is to explore the association of aberrant LATS2 expression with EGFR mutation and survival in lung adenocarcinoma (AD), and the effects of LATS2 silencing in both lung AD cell lines. METHODS: LATS2 mRNA and protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24976335
DOI: 10.1016/j.lungcan.2014.05.025
PMCID: PMC4451109

Genes

LATS2
EGFR

Provenance

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