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Article

A Nonradioactive Uptake Assay for Rapid Analysis of Thyroid Hormone Transporter Function

24 Apr 2015

Abstract excerpt

Thyroid hormones (TH) are actively taken up into target cells via TH-transmembrane transporters (THTT). Their activity and expression patterns define a layer of endocrine regulation that is poorly understood. Therefore, THTT are potential targets for interfering agents (endocrine disruptors) as well as for pharmacological interventions. Inactivating mutations have been identified as the underlying cause of...

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PMID: 25910050
DOI: 10.1210/en.2015-1016

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