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Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8

21 Jan 2017

Abstract excerpt

Thyroid hormones (THs) play important roles in almost all physiological processes. High-throughput screening (HTS) assays are needed to screen the vast numbers of chemicals for their potential to disrupt TH signalling. The current work has confirmed the ability of a rapid assay to identify substances inhibiting TH uptake through monocarboxylate transporter (MCT) 8. Perturbation of MCT8 function results in...

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PMID: 28119167
DOI: 10.1016/j.tiv.2017.01.014

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