Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study.

doi:10.1093/cid/cix128

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Implications of Failure to Routinely Diagnose Resistance to Second-Line Drugs in Patients With Rifampicin-Resistant Tuberculosis on Xpert MTB/RIF: A Multisite Observational Study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2017

Jacobson Karen R, Barnard Marinus, Kleinman Mary B, Streicher Elizabeth M, Ragan Elizabeth J, White Laura F, Shapira Ofer, Dolby Tania, Simpson John, Scott Lesley, Stevens Wendy, van Helden Paul D, Van Rie Annelies, Warren Robin M

Abstract excerpt

BACKGROUND.: Xpert MTB/RIF (Xpert) detects rifampicin-resistant tuberculosis (RR-tuberculosis), enabling physicians to rapidly initiate a World Health Organization-recommended 5-drug regimen while awaiting second-line drug-susceptibility test (DST) results. We quantified the second-line DST results time and proportion of patients potentially placed on suboptimal therapy. METHODS.: We included RR-tuberculosis...

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PMID: 28199520
DOI: 10.1093/cid/cix128
PMCID: PMC5434334

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