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Article

Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma.

PloS one - 1 Jan 2015

Dong Hua, Zhang Lan, Qian Ziliang, Zhu Xuehua, Zhu Guanshan, Chen Yunqin, Xie Xiaoying, Ye Qinghai, Zang Jie, Ren Zhenggang, Ji Qunsheng

Abstract excerpt

To gain molecular insights of HBV integration that may contribute to HCC tumorigenesis, we performed whole transcriptome sequencing and whole genome copy number profiling of hepatocellular carcinoma (HCC) samples from 50 Chinese patients. We identified a total of 33 HBV-human integration sites in 16 of 44 HBV-positive HCC tissues, which were enriched in HBV genotype C-infected patients. In addition, significantly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genome, Human

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Source

Open in PubMed Open full text

Identifiers

PMID: 25901726
DOI: 10.1371/journal.pone.0123175
PMCID: PMC4406717

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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