Article
Genetic variation in the serotonin receptor gene affects immune responses in rheumatoid arthritis.
Genes and immunity - 1 Mar 2013
Snir O, Hesselberg E, Amoudruz P, Klareskog L, Zarea-Ganji I, Catrina A I, Padyukov L, Malmström V, Seddighzadeh M
Abstract excerpt
Many genetic variants associate with the risk of developing rheumatoid arthritis (RA); however, their functional roles are largely unknown. Here, we aimed to investigate whether the RA-associated serotonin receptor 2A (HTR2A) haplotype affects T-cell and monocyte functions. Patients with established RA (n=379) were genotyped for two single-nucleotide polymorphisms (SNPs) in the HTR2A locus, rs6314 and rs1328674,...
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