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Article

miRNA analysis reveals novel dysregulated pathways in amyotrophic lateral sclerosis.

Human molecular genetics - 6 Mar 2023

Hur Junguk, Paez-Colasante Ximena, Figueroa-Romero Claudia, Lo Ting-Wen, Barmada Sami J, Paulsen Michelle T, Ljungman Mats, Alakwaa Fadhl M, Savelieff Masha G, Goutman Stephen A, Feldman Eva L

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Its complex pathogenesis and phenotypic heterogeneity hinder therapeutic development and early diagnosis. Altered RNA metabolism is a recurrent pathophysiologic theme, including distinct microRNA (miRNA) profiles in ALS tissues. We profiled miRNAs in accessible biosamples, including skin fibroblasts and whole blood and compared them in age-...

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Identifiers

PMID: 36219176
DOI: 10.1093/hmg/ddac250
PMCID: PMC9990999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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