Article

Development of recombinant monoclonal antibodies targeting conserved VlsE epitopes in Lyme disease pathogens

2022-05-06

Abstract excerpt

VlsE ( v ariable major protein- l ike s equence, e xpressed) is an outer surface protein of the Lyme disease pathogen ( Borreliella species) and a key diagnostic biomarker of Lyme disease. However, the high sequence variability of VlsE poses a challenge to the development of consistent VlsE-based diagnostics and therapeutics. In addition, the standard diagnostic protocols detect immunoglobins elicited by the...

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Literature Corpus work: 2d82eb74-800d-50d6-9bb4-c1f0d02acbdf
DOI: 10.1101/2022.05.05.490853

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