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Histo‐genomic stratification reveals the frequent amplification/overexpression of CCNE 1 and BRD 4 genes in non‐BRCAness high grade ovarian carcinoma

17 Apr 2015

Abstract excerpt

The treatment of epithelial ovarian cancer (EOC) is narrowly focused despite the heterogeneity of this disease in which outcomes remain poor. To stratify EOC patients for targeted therapy, we developed an approach integrating expression and genomic analyses including the BRCAness status. Gene expression and genomic profiling were used to identify genes recurrently (>5%) amplified and overexpressed in 105 EOC. The...

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PMID: 25892415
DOI: 10.1002/ijc.29568

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