Methylation of NR3C1 and SLC6A4 and internalizing problems. The TRAILS study.

doi:10.1016/j.jad.2015.03.056

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Article

Methylation of NR3C1 and SLC6A4 and internalizing problems. The TRAILS study.

Journal of affective disorders - 15 Jul 2015

van der Knaap Lisette J, van Oort Floor V A, Verhulst Frank C, Oldehinkel Albertine J, Riese Harriëtte

Abstract excerpt

BACKGROUND: The relationship between early adverse life events and later internalizing problems could be mediated by DNA methylation. Adversity has been associated with higher methylation levels in the glucocorticoid receptor gene (NR3C1) and the serotonin transporter gene (SLC6A4) in adolescents...

Topics

Adolescent
Cross-Sectional Studies
DNA Methylation
Diagnostic and Statistical Manual of Mental Disorders
Female
Genetic Predisposition to Disease
Humans
Male
Mental Disorders
Prospective Studies
Receptors, Glucocorticoid
Serotonin Plasma Membrane Transport Proteins
Young Adult

Source

Open in PubMed

Identifiers

PMID: 25889020
DOI: 10.1016/j.jad.2015.03.056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25889020-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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