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Article

Methylation of NR3C1 and SLC6A4 and internalizing problems. The TRAILS study.

Journal of affective disorders - 15 Jul 2015

van der Knaap Lisette J, van Oort Floor V A, Verhulst Frank C, Oldehinkel Albertine J, Riese Harriëtte

Abstract excerpt

BACKGROUND: The relationship between early adverse life events and later internalizing problems could be mediated by DNA methylation. Adversity has been associated with higher methylation levels in the glucocorticoid receptor gene (NR3C1) and the serotonin transporter gene (SLC6A4) in adolescents. We investigated cross-sectional and prospective associations of NR3C1 and SLC6A4 methylation with adolescents׳...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25889020
DOI: 10.1016/j.jad.2015.03.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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