Article
The effect of rare variants on inflation of the test statistics in case-control analyses.
BMC bioinformatics - 20 Feb 2015
Pirie Ailith, Wood Angela, Lush Michael, Tyrer Jonathan, Pharoah Paul D P
Abstract excerpt
BACKGROUND: The detection of bias due to cryptic population structure is an important step in the evaluation of findings of genetic association studies. The standard method of measuring this bias in a genetic association study is to compare the observed median association test statistic to the expected median test statistic. This ratio is inflated in the presence of cryptic population structure. However,...
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