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Article

Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease

18 Mar 2015

Abstract excerpt

BACKGROUND: Patients with Alzheimer's disease (AD) frequently experience disruption of their circadian rhythms, but whether and how circadian clock molecules are perturbed by AD remains unknown. AD is an age-related neurological disorder and amyloid-β (Aβ) is one of major causative molecules in the pathogenesis of AD. RESULTS: In this study, we investigated the role of Aβ in the regulation of clock molecules and...

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PMID: 25888034
DOI: 10.1186/s13024-015-0007-x

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