Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk.

doi:10.1186/s12885-015-1224-y

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Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk.

BMC cancer - 2 Apr 2015

Judkins Thaddeus, Leclair Benoît, Bowles Karla, Gutin Natalia, Trost Jeff, McCulloch James, Bhatnagar Satish, Murray Adam, Craft Jonathan, Wardell Bryan, Bastian Mark, Mitchell Jeffrey, Chen Jian, Tran Thanh, Williams Deborah, Potter Jennifer, Jammulapati Srikanth, Perry Michael, Morris Brian, Roa Benjamin, Timms Kirsten

Abstract excerpt

BACKGROUND: Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of risk for developing cancer. Traditional methods using Sanger sequencing focus on small groups of genes and therefore are unable to screen for numerous genes from several patients simultaneously....

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Identifiers

PMID: 25886519
DOI: 10.1186/s12885-015-1224-y
PMCID: PMC4391687

Genes

BRCA1
BRCA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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