Article
In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors.
BMC cancer - 7 Apr 2015
Barbieri Federica, Thellung Stefano, Ratto Alessandra, Carra Elisa, Marini Valeria, Fucile Carmen, Bajetto Adriana, Pattarozzi Alessandra, Würth Roberto, Gatti Monica, Campanella Chiara, Vito Guendalina, Mattioli Francesca, Pagano Aldo, Daga Antonio, Ferrari Angelo, Florio Tullio
Abstract excerpt
BACKGROUND: Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-therapy to several neoplasias. Nowadays, th (about 10mM)e pharmacological targeting of CSCs is considered an ineludible therapeutic goal. The antidiabetic drug...
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