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Article

Genetic suppression of precocious transcription termination identifies mutations in essential subunits of the fission yeast cleavage and polyadenylation machinery.

RNA (New York, N.Y.) - 16 Oct 2025

Innokentev Aleksei, Sanchez Ana M, Bednor Lauren, Babor Jill, Schwer Beate, Shuman Stewart

Abstract excerpt

The fission yeast phosphate acquisition (PHO) regulon is repressed under phosphate-replete conditions by upstream lncRNA-mediated transcriptional interference. Inositol-1-pyrophosphates control phosphate homeostasis via their action as agonists of precocious PHO lncRNA 3'-processing/termination. Inositol pyrophosphatase-inactivating mutations that increase inositol-1-pyrophosphates elicit derepression of the PHO...

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Share to mRNA Cleavage and Polyadenylation Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polyadenylation

Share to Pyrophosphatases

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Source

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Identifiers

PMID: 40908147
DOI: 10.1261/rna.080664.125
PMCID: PMC12530128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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