Article
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility.
Molecular neurodegeneration - 9 Apr 2015
Sevlever Daniel, Zou Fanggeng, Ma Li, Carrasquillo Sebastian, Crump Michael G, Culley Oliver J, Hunter Talisha A, Bisceglio Gina D, Younkin Linda, Allen Mariet, Carrasquillo Minerva M, Sando Sigrid B, Aasly Jan O, Dickson Dennis W, Graff-Radford Neill R, Petersen Ronald C, Deák Ferenc, Belbin Olivia
Abstract excerpt
BACKGROUND: Alzheimer's disease is a neurodegenerative disorder in which extracellular deposition of β-amyloid (Aβ) oligomers causes synaptic injury resulting in early memory loss, altered homeostasis, accumulation of hyperphosphorylated tau and cell death. Since proteins in the SNAP (Soluble N-ethylmaleimide-sensitive factor Attachment Protein) REceptors (SNARE) complex are essential for neuronal Aβ release at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.