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Article

The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila

16 Apr 2015

Abstract excerpt

Little is known about the tolerance mechanisms that reduce the negative effects of microbial infection on host fitness. Here, we demonstrate that the histone H3 lysine 9 methyltransferase G9a regulates tolerance to virus infection by shaping the response of the evolutionary conserved Jak-Stat pathway in Drosophila. G9a-deficient mutants are more sensitive to RNA virus infection and succumb faster to infection...

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PMID: 25880195
DOI: 10.1371/journal.ppat.1004692

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