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Engineered Aedes aegypti JAK/STAT Pathway-Mediated Immunity to Dengue Virus

12 Jan 2017

Abstract excerpt

We have developed genetically modified Ae. aegypti mosquitoes that activate the conserved antiviral JAK/STAT pathway in the fat body tissue, by overexpressing either the receptor Dome or the Janus kinase Hop by the blood feeding-induced vitellogenin (Vg) promoter. Transgene expression inhibits infection with several dengue virus (DENV) serotypes in the midgut as well as systemically and in the salivary glands....

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PMID: 28081143
DOI: 10.1371/journal.pntd.0005187

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