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Article

Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels.

Molecular psychiatry - 1 Nov 2013

Jacobs M M, Ökvist A, Horvath M, Keller E, Bannon M J, Morgello S, Hurd Y L

Abstract excerpt

Opioid drugs are highly addictive and their abuse has a strong genetic load. Dopamine-glutamate interactions are hypothesized to be important for regulating neural systems central for addiction vulnerability. Balanced dopamine-glutamate interaction is mediated through several functional associations, including a physical link between discs, large homolog 4 (Drosophila) (DLG4, PSD-95) and dopamine receptor 1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23044706
DOI: 10.1038/mp.2012.140
PMCID: PMC3637428

Genes

DRD1
DLG4
HOMER1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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