Article
A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics.
The pharmacogenomics journal - 1 Feb 2016
Cornejo-García J A, Romano A, Guéant-Rodríguez R M, Oussalah A, Blanca-López N, Gaeta F, Tramoy D, Josse T, Doña I, Torres M J, Canto G, Blanca M, Guéant J-L
Abstract excerpt
Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the associat...
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