Article
BRAF V600E mutation in colorectal cancer is associated with right-sided tumours and iron deficiency anaemia.
Anticancer research - 1 Apr 2015
Sideris Michail, Adams Katie, Moorhead Jane, Diaz-Cano Salvador, Bjarnason Ingvar, Papagrigoriadis Savvas
Abstract excerpt
BACKGROUND: BRAF gene encodes a serinethreonine kinase that inhibits the RAS/MAPK intracellular pathway. BRAF mutations occur at an early stage of colorectal cancer and their presence, 10-20% of colorectal cancer (CRC), is usually associated with inferior prognosis. MATERIALS AND METHODS: From 41 consecutive CRC confirmed referrals from 1,446 suspected cancer cases (mean age=67.99+13.451, male=21, female=20), we...
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