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Article

Targeting SUMO Signaling to Wrestle Cancer

19 Dec 2020

Abstract excerpt

The small ubiquitin-like modifier (SUMO) signaling cascade is critical for gene expression, genome integrity, and cell cycle progression. In this review, we discuss the important role SUMO may play in cancer and how to target SUMO signaling. Recently developed small molecule inhibitors enable therapeutic targeting of the SUMOylation pathway. Blocking SUMOylation not only leads to reduced cancer cell proliferation...

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PMID: 33353838
DOI: 10.1016/j.trecan.2020.11.009

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