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Reactive metabolites and antioxidant gene polymorphisms in Type 2 diabetes mellitus

11 Dec 2013

Abstract excerpt

Type 2 diabetes mellitus (T2DM), by definition is a heterogeneous, multifactorial, polygenic syndrome which results from insulin receptor dysfunction. It is an outcome of oxidative stress caused by interactions of reactive metabolites (RMs) interactions with lipids, proteins and other mechanisms of human body. Production of RMs mainly superoxide (O2(-)) has been found in a variety of predominating cellular enzyme...

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PMID: 25460725
DOI: 10.1016/j.redox.2013.12.001

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