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Article

The peroxisomal protein import machinery displays a preference for monomeric substrates.

Open biology - 1 Apr 2015

Freitas Marta O, Francisco Tânia, Rodrigues Tony A, Lismont Celien, Domingues Pedro, Pinto Manuel P, Grou Cláudia P, Fransen Marc, Azevedo Jorge E

Abstract excerpt

Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported by the shuttling receptor PEX5 to the peroxisomal membrane docking/translocation machinery, where they are translocated into the organelle matrix. Under certain experimental conditions this protein import machinery...

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Source

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Identifiers

PMID: 25854684
DOI: 10.1098/rsob.140236
PMCID: PMC4422123

Genes

ACOX1
PEX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25854684-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The peroxisomal protein import machinery displays a preference for monomeric substrates.PMID 25854684Read ↗

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.Semantic proximity Read ↗

Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica.Semantic proximity Read ↗

Pex5p imports folded tetrameric catalase by interaction with Pex13p.Semantic proximity Read ↗

PEX1 <sup>G843D</sup> remains functional in peroxisome biogenesis but is rapidly degraded by the proteasomeSemantic proximity Read ↗

Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol.Semantic proximity Read ↗

The import receptor Pex7p and the PTS2 targeting sequence.Semantic proximity Read ↗

Ubiquitination of the peroxisomal import receptor Pex5p.Semantic proximity Read ↗

Import of peroxisomal matrix and membrane proteins.Semantic proximity Read ↗

The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.Semantic proximity Read ↗

Shuttling mechanism of peroxisome targeting signal type 1 receptor Pex5: ATP-independent import and ATP-dependent export.Semantic proximity Read ↗

Functional domains and dynamic assembly of the peroxin Pex14p, the entry site of matrix proteins.Semantic proximity Read ↗

The PEX1 ATPase Stabilizes PEX6 and Plays Essential Roles in Peroxisome Biology.Semantic proximity Read ↗

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