Article
Ubiquitination of the peroxisomal import receptor Pex5p.
The Biochemical journal - 15 Nov 2004
Platta Harald W, Girzalsky Wolfgang, Erdmann Ralf
Abstract excerpt
Proteins harbouring a peroxisomal targeting signal of type 1 (PTS1) are recognized by the import receptor Pex5p in the cytosol which directs them to a docking and translocation complex at the peroxisomal membrane. We demonstrate the ubiquitination of Pex5p in cells lacking components of the peroxisomal AAA (ATPases associated with various cellular activities) or Pex4p-Pex22p complexes of the peroxisomal protein...
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