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Article

Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.

PloS one - 1 Jan 2015

Loesch Kimberly, Galaviz Stacy, Hamoui Zaher, Clanton Ryan, Akabani Gamal, Deveau Michael, DeJesus Michael, Ioerger Thomas, Sacchettini James C, Wallis Deeann

Abstract excerpt

Elucidating the genetic determinants of radiation response is crucial to optimizing and individualizing radiotherapy for cancer patients. In order to identify genes that are involved in enhanced sensitivity or resistance to radiation, a library of stable mutant murine embryonic stem cells (ESCs), each with a defined mutation, was screened for cell viability and gene expression in response to radiation exposure....

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Identifiers

PMID: 25853515
DOI: 10.1371/journal.pone.0120534
PMCID: PMC4390347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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