Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.

PloS one - 1 Jan 2015

Ricigliano Vito A G, Handel Adam E, Sandve Geir K, Annibali Viviana, Ristori Giovanni, Mechelli Rosella, Cader M Zameel, Salvetti Marco

Abstract excerpt

Epstein-Barr virus (EBV) is a non-heritable factor that associates with multiple sclerosis (MS). However its causal relationship with the disease is still unclear. The virus establishes a complex co-existence with the host that includes regulatory influences on gene expression. Hence, if EBV contributes to the pathogenesis of MS it may do so by interacting with disease predisposing genes. To verify this...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epstein-Barr Virus Nuclear Antigens
Share to VDR gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Human

Share to Multiple Sclerosis

Share to Polymorphism, Single Nucleotide

Share to Protein Binding

Share to Protein Transport

Share to Receptors, Calcitriol

Source

Open in PubMed Open full text

Identifiers

PMID: 25853421
DOI: 10.1371/journal.pone.0119605
PMCID: PMC4390304

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

EBNA2 binds to genomic intervals associated with multiple sclerosis and overlaps with vitamin D receptor occupancy.PMID 25853421Read ↗

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosisSemantic proximity Read ↗

Epstein-Barr virus nuclear antigen 2 (EBNA2) extensively rewires the human chromatin landscape at autoimmune risk lociSemantic proximity Read ↗

A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosisSemantic proximity Read ↗

Vitamin D receptor binding, chromatin states and association with multiple sclerosisSemantic proximity Read ↗

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis.Semantic proximity Read ↗

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype.Semantic proximity Read ↗

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus associationSemantic proximity Read ↗

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunitiesSemantic proximity Read ↗

Genomic binding sites and biological effects of the vitamin D--VDR complex in multiple sclerosis [corrected].Semantic proximity Read ↗

Significant enrichment of Herpesvirus interactors in GWAS data suggests causal inferences for the association between Epstein Barr virus and multiple sclerosisSemantic proximity Read ↗

Gender and the Sex Hormone Estradiol Affect Multiple Sclerosis Risk Gene Expression in Epstein-Barr Virus-Infected B Cells.Semantic proximity Read ↗

Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.