Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gender and the Sex Hormone Estradiol Affect Multiple Sclerosis Risk Gene Expression in Epstein-Barr Virus-Infected B Cells.

Frontiers in immunology - 1 Jan 2021

Keane Jeremy T, Afrasiabi Ali, Schibeci Stephen D, Fewings Nicole, Parnell Grant P, Swaminathan Sanjay, Booth David R

Abstract excerpt

Multiple Sclerosis (MS) is a complex immune-mediated disease of the central nervous system. Treatment is based on immunomodulation, including specifically targeting B cells. B cells are the main host for the Epstein-Barr Virus (EBV), which has been described as necessary for MS development. Over 200 genetic loci have been identified as increasing susceptibility to MS. Many MS risk genes have altered expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene-Environment Interaction

Share to Gonadal Steroid Hormones

Share to Herpesvirus 4, Human

Share to Host-Pathogen Interactions

Share to Multiple Sclerosis

Share to Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 34566997
DOI: 10.3389/fimmu.2021.732694
PMCID: PMC8455923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gender and the Sex Hormone Estradiol Affect Multiple Sclerosis Risk Gene Expression in Epstein-Barr Virus-Infected B Cells.PMID 34566997Read ↗

A disease-specific convergence of host and Epstein–Barr virus genetics in multiple sclerosisSemantic proximity Read ↗

The interaction of Multiple Sclerosis risk loci with Epstein-Barr virus phenotypes implicates the virus in pathogenesis.Semantic proximity Read ↗

Transcriptomic Profile Reveals Gender-Specific Molecular Mechanisms Driving Multiple Sclerosis ProgressionSemantic proximity Read ↗

The interaction between Epstein–Barr virus and multiple sclerosis genetic risk loci: insights into disease pathogenesis and therapeutic opportunitiesSemantic proximity Read ↗

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosisSemantic proximity Read ↗

Evidence from genome wide association studies implicates reduced control of Epstein-Barr virus infection in multiple sclerosis susceptibilitySemantic proximity Read ↗

Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms.Semantic proximity Read ↗

Epstein Barr Virus Exploits Genetic Susceptibility to Increase Multiple Sclerosis RiskSemantic proximity Read ↗

Enrichment analysis of GWAS data in autoimmunity delineates the multiple sclerosis-Epstein Barr virus associationSemantic proximity Read ↗

Identification of multiple sclerosis-related genes regulated by EBV-encoded microRNAs in B cellsSemantic proximity Read ↗

A deep transcriptome meta-analysis reveals sex differences in multiple sclerosisSemantic proximity Read ↗

Epstein-Barr Virus-Induced Genes and Endogenous Retroviruses in Immortalized B Cells from Patients with Multiple SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.