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Article

The interaction of Epstein-Barr virus encoded transcription factor EBNA2 with multiple sclerosis risk loci is dependent on the risk genotype.

EBioMedicine - 1 Sept 2021

Keane Jeremy Thomas, Afrasiabi Ali, Schibeci Stephen Donald, Swaminathan Sanjay, Parnell Grant Peter, Booth David Richmond

Abstract excerpt

BACKGROUND: Epstein-Barr virus (EBV) infection may be necessary for the development of Multiple sclerosis (MS). Earlier we had identified six MS risk loci that are co-located with binding sites for the EBV transcription factor Epstein-Barr Nuclear Antigen 2 (EBNA2) in EBV-infected B cells (lymphoblastoid cell lines - LCLs). METHODS: We used an allele-specific chromatin immunoprecipitation PCR assay to assess...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34488019
DOI: 10.1016/j.ebiom.2021.103572
PMCID: PMC8426200

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